Endocrine Abstracts

Introduction: In the etiology of thyroid dysgenesis (TD) an interplay between genetic and environmental factors is thought to play a crucial role. Data from previous studies on association between the season of birth and the incidence of TD causing congenital hypothyroidism (mainly agenesis and ectopy) are conflicting. To date, seasonality of births have not been analysed yet in regard to congenital absence of one thyroid lobe (thyroid hemiagenesis, THA).<p class="abstext"...

Incidence of acute thyroiditis is about 0.1% of thyroid gland conditions requiring surgical treatment. Main pathogen causing acute thyroiditis is Staphylococcus aureus while Salmonella enterica is extremely rare.Herewith we report a 61-year-old obese woman with sore throat and fever. She had chronic atrial fibrillation, hypertension, and well-controlled type 2 diabetes mellitus (HbA1C 5.5%) for 3 years (on metformin and gliclazide). Her...

Thyrotropinoma is a very rare cause of hyperthyroidism. In October 2014 a 41-year-old male patient was examined for anaemia and diarrhoea. Abdomen CT scan, gastroscopy, colonoscopy and parasite tests did not reveal any abnormalities. The patient had lost 18 kg 7 years ago and his weight had been stable since then (BMI 21.3 kg/m2). The laboratory tests revealed high TSH, normal fT4 and low cortisol level. The patient referred to our department presented wi...

Introduction: Hyperparathyroidism during pregnancy is a serious problem. Appropriate management is a matter of debate. We would like to present cases in which, PHP was diagnosed in completely different circumstances, though end up with various pregnancy outcomes.Case report: First patient was 29-year-old women in 21th week of her second pregnancy admitted to our ward due to suspected relapse of Graves’ disease and possible adrenal dysfunction. She p...

Introduction: While, both quality and accessibility to novel imaging technics rises, we observe a surge in detection of adrenal masses. Those tumors are accidentally found in ~ 0.4% of ultrasonographies and in 4% of computed tomography scans (CT) conducted due to other indications. In spite of high prevalence of those lesions approach to their diagnosis, follow-up and treatment is still controversial. High financial costs and possible adverse effect on health connected with th...

Introduction: Elastography is a method of tissue stiffness assessment. It was already demonstrated that thyroid cancers are less elastic than benign lesions. However, little is known about other factors, which might influence the stiffness of thyroid nodules and disrupt the prediction of malignancy using this technique. The aim of this study was to conduct the first systematic assessment of factors potentially affecting elasticity of thyroid lesions.Meth...

Introduction: According to a high prevalence and relatively low occurrence of malignancies in thyroid nodular disease (TND), the selection of suspicious lesions for fine – needle aspiration biopsy (FNAB) seem to be a vital problem in the daily endocrinological practice. Beside deciding if the FNAB is necessary, frequently the second problem occurs – which nodule or nodules should be chosen in case of multinodular goiter (MNG), when the number of potential lesions for...

Introduction: Thyroid disorders have significant impact on patients’ quality of life (QoL). ThyPRO is a thyroid-specific QoL questionnaire applicable to patients with benign thyroid disorders. There is substantial evidence for its clinical validity and reliability in patients with benign thyroid disorders. ThyPRO consists of 85 questions summarized in 13 scales, measuring aspects of QoL relevant to thyroid patients. Our aim was to develop a validated Polish version of thi...

Introduction: Thyroid cancer incidence has increased significantly during the past decades and is the most common type of endocrine malignancy. Suitable criteria for detecting malignant thyroid tumors are still missing. Therefore, the discovery of molecular markers linked to thyroid carcinogenesis will be helpful in the diagnosis of malignant tumors and managing their appropriate treatment.Aim: The objective of the study was to evaluate survivin expressi...

In this study, we attempted to demonstrate the expression of GHSR-1a receptor and possible effects of its activation in human, rat and boar spermatozoa. For demonstration of GHSR-1a immunocytochemical, immunofluorescence and western blotting techniques were applied. The effects of receptor activation was tested in a series of in vitro incubations of spermatozoa with or without addition of ghrelin and the effects were evaluated using confocal microscopy and flow cytometr...